Effect of autologous growth factors on radial lesions of the posterior horn of the external meniscus in the rabbit knee: an experimental model

Abstract

Introduction: Currently, meniscal injuries at the popliteal hiatus have a poor prognosis after surgical treatment, while patients almost always expect a long time recovery.

Methods: We performed an experimental self-controlled double-blind study, by performing a radial injury at the posterior horn of the lateral meniscus at the popliteal hiatus in both knees of 18 rabbits. We apply autologous growth factors and platelet-poor plasma to the study group knees whereas the control group did not received it. Both meniscal injuries (study and control groups) were reconstructed by an open technique with an inside – out stitch. Follow up of the specimens were performed at 3 and 6 weeks with a macroscopic and microscopic examination in order to detect differences between the groups.

Results: Significant differences were found out favoring growth factors as healers for meniscal injuries.

Discussion: A study on humans should be conducted, as the use of autologous growth factors is safe, and it´s behave as a healer with an inside – out meniscal stitch is great.