Artificial intelligence in the context of the surgical treatment of scoliosis in adults, with an emphasis on applications, outcomes, and ethical implications: A systematic review

Authors

  • Jheremy Sebastian Reyes-Barreto Cancer and Molecular Medicine Research Group (CAMMO), Bogotá D.C., Colombia. | Universidad de Los Andes, Faculty of Medicine, Bogotá D.C, Colombia. https://orcid.org/0000-0002-7366-0881
  • María Alejandra Rodríguez-Brilla Cancer and Molecular Medicine Research Group (CAMMO), Bogotá D.C., Colombia. | Universidad de Los Andes, Faculty of Medicine, Bogotá D.C, Colombia. https://orcid.org/0009-0004-0068-6601

DOI:

https://doi.org/10.58814/01208845.542

Keywords:

Scoliosis, Orthopedic Surgery, Artificial Intelligence, Postoperative Complications, Medical Ethics

Abstract

Introduction: Artificial intelligence (AI) and machine learning (ML) are being increasingly implemented in the surgical treatment of scoliosis in adults in an effort to enhance precision, optimize outcomes, and support clinical decision-making. Despite significant progress, their use in the clinical setting raises ethical concerns regarding data governance, transparency, and algorithmic bias.

Objective: To systematically review the current evidence on the use of AI in the context of surgical treatment of scoliosis in adults, focusing on its clinical applications, reported outcomes, and associated ethical considerations.

Methodology: This systematic review was conducted in accordance with the PRISMA 2020 guidelines and registered in PROSPERO (CRD42024585554). A comprehensive search was performed in June 2024 across PubMed, ScienceDirect, Scopus, and Google Scholar. Studies addressing the use of AI or ML in the surgical treatment of scoliosis in adults (≥18 years) and reporting clinical applications, surgical outcomes, or ethical implications were included. Quality assessment was performed using the Newcastle-Ottawa Scale.

Results: A total of 304 records were retrieved from the searches. After removing duplicates and screening titles, abstracts, and full-text, 16 studies were included in the review. All studies were published between 2020 and 2024; 8 were observational studies, 1 was a systematic review, and 7 were literature reviews. The combined sample size of observational studies was 43 320 patients (141-39 254). Artificial Neural Networks (ANN), Convolutional Neural Networks (CNN), and Support Vector Machines (SVM) were predominant. Clinical applications encompassed predictive modeling of surgical outcomes, assessment of complication risks, and decision support for surgical planning. AI-enhanced systems showed potential to reduce complications and improve alignment outcomes. However, external validation was limited, and no study included prospective clinical trials. Ethical concerns such as transparency and data bias were acknowledged in only a minority of studies.

Conclusion: AI holds a considerable potential in scoliosis surgery for adults but it is still in early stages of clinical integration. Future research must focus on validation, explainability, and equitable implementation to fully realize its potential in spine surgery.

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References

Zhang H, Huang C, Wang D, Li K, Han X, Chen X, Li Z. Artificial Intelligence in Scoliosis: Current Applications and Future Directions. J Clin Med. 2023;12(23):7382. doi: 10.3390/jcm12237382. PMID: 38068444; PMCID: PMC10707441.

Shi L, Wang H, Shea GK. The Application of Artificial Intelligence in Spine Surgery: A Scoping Review. J Am Acad Orthop Surg Glob Res Rev. 2025;9(4):e24.00405. doi: 10.5435/JAAOSGlobal-D-24-00405. PMID: 40239218; PMCID: PMC11999406.

Patel RV, Yearley AG, Isaac H, Chalif EJ, Chalif JI, Zaidi HA. Advances and Evolving Challenges in Spinal Deformity Surgery. J Clin Med. 2023;12(19):6386. doi: 10.3390/jcm12196386. PMID: 37835030; PMCID: PMC10573859.

Chen X, Feng F, Yu X, Wang S, Tu Z, Han Y, et al. Robot-assisted orthopedic surgery in the treatment of adult degenerative scoliosis: a preliminary clinical report. J Orthop Surg Res. 2020;15(1):282. doi: 10.1186/s13018-020-01796-2. PMID: 32711566; PMCID: PMC7382042.

Cristante AF, Silva RTE, Costa GHRD, Marcon RM. Adult Degenerative Scoliosis. Rev Bras Ortop (Sao Paulo). 2021;56(1):1-8. doi: 10.1055/s-0040-1709736. PMID: 33627892; PMCID: PMC7895612.

Cho KJ, Kim YT, Shin SH, Suk SI. Surgical treatment of adult degenerative scoliosis. Asian Spine J. 2014;8(3):371-81. doi: 10.4184/asj.2014.8.3.371. PMID: 24967054; PMCID: PMC4068860.

McAviney J, Roberts C, Sullivan B, Alevras AJ, Graham PL, Brown BT. The prevalence of adult de novo scoliosis: A systematic review and meta-analysis. Eur Spine J. 2020;29(12):2960-69. doi: 10.1007/s00586-020-06453-0. PMID: 32440771.

Kotwal S, Pumberger M, Hughes A, Girardi F. Degenerative scoliosis: a review. HSS J. 2011;7(3):257-64. doi: 10.1007/s11420-011-9204-5. PMID: 23024623; PMCID: PMC3192887.

Aebi M. The adult scoliosis. Eur Spine J. 2005;14(10):925-48. doi: 10.1007/s00586-005-1053-9. PMID: 16328223.

Mohammed ZJ, Worley J, Hiatt L, Rajaram Manoharan SR, Theiss S. Limited Intervention in Adult Scoliosis-A Systematic Review. J Clin Med. 2024;13(4):1030. doi: 10.3390/jcm13041030. PMID: 38398343; PMCID: PMC10888624.

Wang C, Chang H, Gao X, Xu J, Meng X. Risk factors of degenerative lumbar scoliosis in patients with lumbar spinal canal stenosis. Medicine (Baltimore). 2019;98(38):e17177. doi: 10.1097/MD.0000000000017177. PMID: 31567958; PMCID: PMC6756698.

Hornung AL, Hornung CM, Mallow GM, Barajas JN, Rush A 3rd, Sayari AJ, et al. Artificial intelligence in spine care: current applications and future utility. Eur Spine J. 2022;31(8):2057-81. doi: 10.1007/s00586-022-07176-0. PMID: 35347425.

Wagner DT, Tilmans L, Peng K, Niedermeier M, Rohl M, Ryan S, et al. Artificial Intelligence in Neuroradiology: A Review of Current Topics and Competition Challenges. Diagnostics (Basel). 2023;13(16):2670. doi: 10.3390/diagnostics13162670. PMID: 37627929; PMCID: PMC10453240.

Khan MM, Chaurasia B. Artificial intelligence and its use in spine surgery and preparation of predictive models: a systematic review. Ann Med Surg (Lond). 2025;87(1):171-6. doi: 10.1097/MS9.0000000000002782. PMID: 40109595; PMCID: PMC11918546.

Yahanda AT, Joseph K, Bui T, Greenberg JK, Ray WZ, Ogunlade JI, et al. Current Applications and Future Implications of Artificial Intelligence in Spine Surgery and Research: A Narrative Review and Commentary. Global Spine J. 2025;15(2):1445-54. doi: 10.1177/21925682241290752. PMID: 39359113; PMCID: PMC11559723.

Lee NJ, Lombardi JM, Lehman RA. Artificial Intelligence and Machine Learning Applications in Spine Surgery. Int J Spine Surg. 2023;17(S1):S18-S25. doi: 10.14444/8503. PMID: 37193608; PMCID: PMC10318911.

Fabijan A, Polis B, Fabijan R, Zakrzewski K, Nowosławska E, Zawadzka-Fabijan A. Artificial Intelligence in Scoliosis Classification: An investigation of Language-Based Models. J Pers Med. 2023;13(12):1695. doi: 10.3390/jpm13121695.PMID: 38138922; PMCID: PMC10744696.

Li H, Qian C, Yan W, Fu D, Zheng Y, Zhang Z, et al. Use of Artificial Intelligence in Cobb angle Measurement for Scoliosis: Retrospective Reliability and Accuracy Study of a Mobile App. J Med Internet Res. 2024;26:e50631. doi: 10.2196/50631. PMID: 39486021; PMCID: PMC11568394..

Fabijan A, Zawadzka-Fabijan A, Fabijan R, Zakrzewski K, Nowosławska E, Polis B. Assessing the Accuracy of Artificial Intelligence Models in Scoliosis Classification and Suggested Therapeutic Approaches. J Clin Med. 2024;13(14):4013. doi: 10.3390/jcm13144013. PMID: 39064053; PMCID: PMC11278075.

Fabijan A, Zawadzka-Fabijan A, Fabijan R, Zakrzewski K, Nowosławska E, Polis B. Artificial Intelligence in Medical Imaging: Analyzing the Performance of ChatGPT and Microsoft Bing in Scoliosis Detection and Cobb Angle Assessment. Diagnostics (Basel). 2024;14(7):773. doi: 10.3390/diagnostics14070773. PMID: 38611686; PMCID: PMC11011528.

Wang J, Miao J, Zhan Y, Duan Y, Wang Y, Hao D, Wang B. Spine Surgical Robotics: Current Status and Recent Clinical Applications. Neurospine. 2023;20(4):1256-71. doi: 10.14245/ns.2346610.305. PMID: 38171293; PMCID: PMC10762389.

Yang CH, Chen WC, Chen JB, Huang HC, Chuang LY. Overall mortality risk analysis for rectal cancer using deep learning-based fuzzy systems. Comput Biol Med. 2023;157:106706. doi: 10.1016/j.compbiomed.2023.106706. PMID: 36965323.

Zhang T, Zhu C, Zhao Y, Zhao M, Wang Z, Song R, et al. Deep Learning Model to Classify and Monitor Idiopathic Scoliosis in Adolescents Using a Single Smartphone Photograph. JAMA Netw Open. 2023;6(8):e2330617. doi: 10.1001/jamanetworkopen.2023.30617. PMID: 37610748; PMCID: PMC10448299.

Greenberg JK, Landman JM, Kelly MP, Pennicooke BH, Molina CA, Foraker RE, et al. Leveraging Artificial Intelligence and Synthetic Data Derivatives for Spine Surgery Research. Global Spine J. 2023;13(8):2409--21. doi: 10.1177/21925682221085535. PMID: 35373623; PMCID: PMC10538345.

Haddas R, Ju KL, Boah A, Kosztowski T, Derman PB. The Effect of Surgical Decompression on Functional Balance Testing in Patients with Cervical Spondylotic Myelopathy. Clin Spine Surg. 2019;32(9):369-76. doi: 10.1097/BSD.0000000000000889. PMID: 31498275.

Haddaway NR, Page MJ, Pritchard CC, McGuinness LA. PRISMA2020: An R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis. Campbell Syst Rev. 2022;18(2):e1230. doi: 10.1002/cl2.1230. PMID: 36911350; PMCID: PMC8958186.

Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and metaanalyses: the PRISMA statement. PLoS Med. 2009;6 (7):e1000097. doi: 10.1371/journal.pmed.1000097. PMID: 19621072; PMCID: PMC2707599.

Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016;5(1):210. doi: 10.1186/s13643-016-0384-4. PMID: 27919275; PMCID: PMC5139140.

Ottawa Hospital Research Institute. Clinical Epidemiology Program [Internet]. Ottawa: Ottawa Hospital Research Institute; [cited 2025 Jun 4]. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.

Scheer JK, Ames CP. Artificial intelligence in spine surgery. Neurosurg Clin N Am. 2024;35(2):253--62. doi: 10.1016/j.nec.2023.11.001. PMID: 38423741.

Charles YP, Lamas V, Ntilikina Y. Artificial intelligence and treatment algorithms in spine surgery. Orthop Traumatol Surg Res. 2023;109(1S):103456. doi: 10.1016/j.otsr.2022.103456. PMID: 36302452.

Kamalapathy PN, Karhade AV, Tobert D, Schwab JH. Artificial intelligence in adult spinal deformity. Acta Neurochir Suppl. 2022;134:313-8. doi: 10.1007/978-3-030-85292-4_35. PMID: 34862555.

Lee NJ, Lombardi JM, Lehman RA. Artificial Intelligence and Machine Learning Applications in Spine Surgery. Int J Spine Surg. 2023;17(S1):S18--25. doi: 10.14444/8503. PMID: 37193608; PMCID: PMC10318911.

Joshi RS, Lau D, Ames CP. Artificial intelligence for adult spinal deformity: current state and future directions. Spine J. 2021;21(10):1626-34. doi: 10.1016/j.spinee.2021.04.019. PMID: 33971322.

Johnson GW, Chanbour H, Ali MA, Chen J, Metcalf T, Doss D, et al. Artificial Intelligence to Preoperatively Predict Proximal Junction Kyphosis Following Adult Spinal Deformity Surgery: Soft Tissue Imaging May Be Necessary for Accurate Models. Spine (Phila Pa 1976). 2023;48(23):1688-95. doi: 10.1097/BRS.0000000000004816. PMID: 37644737; PMCID: PMC11101214.

Hussein YY, Khan MM. Using Artificial Intelligence to Predict the Development of Kyphosis Disease: A Systematic Review. Cureus. 2023;15(11):e48341. doi: 10.7759/cureus.48341. PMID: 38060748; PMCID: PMC10698623.

Durand WM, Lafage R, Hamilton DK, Passias PG, Kim HJ, Protopsaltis T, et al. Artificial intelligence clustering of adult spinal deformity sagittal plane morphology predicts surgical characteristics, alignment, and outcomes. Eur Spine J. 2021;30(8):2157-66. doi: 10.1007/s00586-021-06799-z. PMID: 33856551.

Joshi RS, Lau D, Scheer JK, Serra-Burriel M, Vila-Casademunt A, Bess S, et al. State-of-the-art reviews predictive modeling in adult spinal deformity: applications of advanced analytics. Spine Deform. 2021;9(5):1223-39. doi: 10.1007/s43390-021-00360-0. PMID: 34003461; PMCID: PMC8363545.

Patel AV, White CA, Schwartz JT, Pitaro NL, Shah KC, Singh S, et al. Emerging Technologies in the Treatment of Adult Spinal Deformity. Neurospine. 2021;18(3):417-27. doi: 10.14245/ns.2142412.206. PMID: 34610669; PMCID: PMC8497255.

Durand WM, Daniels AH, Hamilton DK, Passias P, Kim HJ, Protopsaltis T, et al. Artificial Intelligence Models Predict Operative Versus Nonoperative Management of Patients with Adult Spinal Deformity with 86% Accuracy. World Neurosurg. 2020;141:e239-53. doi: 10.1016/j.wneu.2020.05.099. PMID: 32434029.

De la Garza Ramos R, Hamad MK, Ryvlin J, Krol O, Passias PG, Fourman MS, et al. An Artificial Neural Network Model for the Prediction of Perioperative Blood Transfusion in Adult Spinal Deformity Surgery. J Clin Med. 2022;11(15):4436. doi: 10.3390/jcm11154436. PMID: 35956053; PMCID: PMC9369471.

Lafage R, Ang B, Alshabab BS, Elysee J, Lovecchio F, Weissman K, et al. Predictive Model for Selection of Upper Treated Vertebra Using a Machine Learning Approach. World Neurosurg. 2021;146:e225-32. doi: 10.1016/j.wneu.2020.10.073. PMID: 33091645.

Haselhuhn JJ, Soriano PBO, Grover P, Dreischarf M, Odland K, Hendrickson NR, et al. Spine surgeon versus AI algorithm full-length radiographic measurements: a validation study of complex adult spinal deformity patients. Spine Deform. 2024;12(3):755-61. doi: 10.1007/s43390-024-00825-y. PMID: 38336942.

Cabrera A, Bouterse A, Nelson M, Razzouk J, Ramos O, Bono CM, et al. Accounting for age in prediction of discharge destination following elective lumbar fusion: a supervised machine learning approach. Spine J. 2023;23(7):997-1006. doi: 10.1016/j.spinee.2023.03.015. PMID: 37028603.

Löchel J, Putzier M, Dreischarf M, Grover P, Urinbayev K, Abbas F, et al. Deep learning algorithm for fully automated measurement of sagittal balance in adult spinal deformity. Eur Spine J. 2024;33(11):4119-24. doi: 10.1007/s00586-023-08109-1. PMID: 38231388.

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Published

2025-09-17

How to Cite

1.
Reyes-Barreto JS, Rodríguez-Brilla MA. Artificial intelligence in the context of the surgical treatment of scoliosis in adults, with an emphasis on applications, outcomes, and ethical implications: A systematic review. Rev. Colomb. Ortop. Traumatol. [Internet]. 2025 Sep. 17 [cited 2026 Mar. 15];39:e542. Available from: https://revistasccotorg.biteca.online/index.php/rccot/article/view/542

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