Medullary compression after diffuse large B cell lymphoma at thoracic spine in an undiagnosed HIV positive patient: A case report
DOI:
https://doi.org/10.1016/j.rccot.2022.10.001Keywords:
Non-Hodgkin’s lymphoma, Spine, HIV infections, Spinal neoplasmsAbstract
Diffuse large B cell lymphoma is a rare kind of non-Hodgkin’s lymphoma that has been associated to HIV infection. This case report presents a male patient with an unusual case of lymphoma in the spine with medullary compression at T12. At the same time, he was diagnosed with a previously unknown HIV infection. The patient is intervened for the acute medullary compression with additional chemotherapy with a R-EPOCH scheme achieving significative improvement after a few weeks.
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Seo JY, Ha KY, Kim MU, Kim YC, Kim YH. Spinal cord compression by B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma in a patient seropositive for human immunodeficiency virus: A case report. J Med Case Rep. 2014;8:1-4, http://dx.doi.org/10.1186/1752-1947-8-324.
Besson C, Lancar R, Prevot S, Algarte-Genin M, Delobel P, Bonnet F, et al. Outcomes for HIV-associated diffuse large B-cell lymphoma in the modern combined antiretroviral therapy era. Aids. 2017;31:2493-501, http://dx.doi.org/10.1097/QAD.0000000000001652.
Castillo J, Pantanowitz L, Dezube BJ. HIV-associated plasmablastic lymphoma: Lessons learned from 112 published cases. Am J Hematol. 2008;83:804-9, http://dx.doi.org/10.1002/ajh.21250.
Moussaly E, Nazha B, Zaarour M, Paul J. Primary Non-Hodgkin’ s Lymphoma of the Spine: A Case Report and Literature Review. 2015;6:459-63, http://dx.doi.org/10.14740/wjon947w.
Kim S-K, Lee S-H, Kim E-S, Eoh W. Diffuse Large B-Cell Lymphoma Mimicking Schwannoma of Lumbar Spine. Korean J Spine. 2016;13:71-3, http://dx.doi.org/10.14245/kjs.2016.13.2.71.
Harris E, Butler JS, Cassidy N. Aggressive plasmablastic lymphoma of the thoracic spine presenting as acute spinal cord compression in a case of asymptomatic undiagnosed human immunodeficiency virus infection. Spine J. 2014;14, http://dx.doi.org/10.1016/j.spinee.2013.12.018.
Wada N, Kohara M, Ikeda J, Hori Y, Fujita S, Okada M, et al., Diffuse large B-cell lymphoma in the spinal epidural space: A study of the Osaka Lymphoma Study Group. Pathol Res Pract. 2010;206:439-44, http://dx.doi.org/10.1016/j.prp.2010.02.003.
Friedberg JW, Fisher RI. Diffuse Large B-Cell Lymphoma. Hematol Oncol Clin North Am. 2008;22, https://doi.org/10.1016/j.hoc.2008.07.002
Córdoba-Mosqueda ME, Guerra-Mora JR, Sánchez-Silva MC, Vicuña-González RM, Torre AI. Primary Spinal Epidural Lymphoma As a Cause of Spontaneous Spinal Anterior Syndrome: A Case Report and Literature Review. 2017:3-6, http://dx.doi.org/10.1055/s-0036-1597692.
Hashi S, Goodwin CR, Ahmed AK, Sciubba DM. Management of extranodal lymphoma of the spine: a study of 30 patients. 2018:7, http://dx.doi.org/10.2217/cns-2017-0033.
Coiffier B. Rituximab in combination with CHOP improves survival in elderly patients with aggressive non-Hodgkin’s lymphoma. Semin Oncol. 2002;29 2 SUPPL. 6:18-22, http://dx.doi.org/10.1053/sonc.2002.32749.
Chang CM, Chen HC, Yang Y, Wang RC, Hwang WL, Teng CLJ. Surgical decompression improves recovery from neurological deficit and may provide a survival benefit in patients with diffuse large B-cell lymphoma-associated spinal cord compression: A case-series study. World J Surg Oncol. 2013;11:1, http://dx.doi.org/10.1186/1477-7819-11-90.
Akgül T, Bilgin Y, Karademir G. The great mimicker at thoracolumbar spine: NonHodgkin’s lymphoma. Int JSurg Case Rep. 2017;39:267-70, http://dx.doi.org/10.1016/j.ijscr.2017.08.034.
Peng X, Wan Y, Chen Y, Chen L, He A, Liao W, et al. Primary non-Hodgkin’s lymphoma of the spine with neurologic compression treated by radiotherapy and chemotherapy alone or combined with surgical decompression. Oncol Rep. 2009 May;21:1269-75, http://dx.doi.org/10.3892/or00000350.
Tang Y, Yang X, Xiao J, Liu K, Yan W, Song D, et al. Clinical outcomes of treatment for spinal cord compression due to primary non-Hodgkin lymphoma. Spine J. 2013;13:641-50, http://dx.doi.org/10.1016/j.spinee.2012.11.054.