Medullary compression after diffuse large B cell lymphoma at thoracic spine in an undiagnosed HIV positive patient: A case report

Authors

  • Helbert Martín-V Pontificia Universidad Javeriana. Bogotá, Colombia
  • Carlos Alberto Sánchez-Correa Pontificia Universidad Javeriana. Bogotá, Colombia
  • Frank Mario Herrera-Méndez Hospital Universitario San Ignacio. Bogotá, Colombia
  • Carlos Segundo Montero-Silva Hospital Universitario San Ignacio. Bogotá, Colombia

DOI:

https://doi.org/10.1016/j.rccot.2022.10.001

Keywords:

Non-Hodgkin’s lymphoma, Spine, HIV infections, Spinal neoplasms

Abstract

Diffuse large B cell lymphoma is a rare kind of non-Hodgkin’s lymphoma that has been associated to HIV infection. This case report presents a male patient with an unusual case of lymphoma in the spine with medullary compression at T12. At the same time, he was diagnosed with a previously unknown HIV infection. The patient is intervened for the acute medullary compression with additional chemotherapy with a R-EPOCH scheme achieving significative improvement after a few weeks.

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Author Biographies

Helbert Martín-V, Pontificia Universidad Javeriana. Bogotá, Colombia

Residente III año Ortopedia y Traumatología, Pontificia Universidad Javeriana, Bogotá, Colombia.

Carlos Alberto Sánchez-Correa, Pontificia Universidad Javeriana. Bogotá, Colombia

Residente III año Ortopedia y Traumatología, Pontificia Universidad Javeriana, Bogotá, Colombia.

Frank Mario Herrera-Méndez, Hospital Universitario San Ignacio. Bogotá, Colombia

Especialista en Cirugía Ortopédica de Columna, Hospital Universitario San Ignacio, Bogotá, Colombia.

Carlos Segundo Montero-Silva, Hospital Universitario San Ignacio. Bogotá, Colombia

Especialista en Cirugía Ortopédica de Columna, Hospital Universitario San Ignacio, Bogotá, Colombia.

References

Seo JY, Ha KY, Kim MU, Kim YC, Kim YH. Spinal cord compression by B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma in a patient seropositive for human immunodeficiency virus: A case report. J Med Case Rep. 2014;8:1-4, http://dx.doi.org/10.1186/1752-1947-8-324.

Besson C, Lancar R, Prevot S, Algarte-Genin M, Delobel P, Bonnet F, et al. Outcomes for HIV-associated diffuse large B-cell lymphoma in the modern combined antiretroviral therapy era. Aids. 2017;31:2493-501, http://dx.doi.org/10.1097/QAD.0000000000001652.

Castillo J, Pantanowitz L, Dezube BJ. HIV-associated plasmablastic lymphoma: Lessons learned from 112 published cases. Am J Hematol. 2008;83:804-9, http://dx.doi.org/10.1002/ajh.21250.

Moussaly E, Nazha B, Zaarour M, Paul J. Primary Non-Hodgkin’ s Lymphoma of the Spine: A Case Report and Literature Review. 2015;6:459-63, http://dx.doi.org/10.14740/wjon947w.

Kim S-K, Lee S-H, Kim E-S, Eoh W. Diffuse Large B-Cell Lymphoma Mimicking Schwannoma of Lumbar Spine. Korean J Spine. 2016;13:71-3, http://dx.doi.org/10.14245/kjs.2016.13.2.71.

Harris E, Butler JS, Cassidy N. Aggressive plasmablastic lymphoma of the thoracic spine presenting as acute spinal cord compression in a case of asymptomatic undiagnosed human immunodeficiency virus infection. Spine J. 2014;14, http://dx.doi.org/10.1016/j.spinee.2013.12.018.

Wada N, Kohara M, Ikeda J, Hori Y, Fujita S, Okada M, et al., Diffuse large B-cell lymphoma in the spinal epidural space: A study of the Osaka Lymphoma Study Group. Pathol Res Pract. 2010;206:439-44, http://dx.doi.org/10.1016/j.prp.2010.02.003.

Friedberg JW, Fisher RI. Diffuse Large B-Cell Lymphoma. Hematol Oncol Clin North Am. 2008;22, https://doi.org/10.1016/j.hoc.2008.07.002

Córdoba-Mosqueda ME, Guerra-Mora JR, Sánchez-Silva MC, Vicuña-González RM, Torre AI. Primary Spinal Epidural Lymphoma As a Cause of Spontaneous Spinal Anterior Syndrome: A Case Report and Literature Review. 2017:3-6, http://dx.doi.org/10.1055/s-0036-1597692.

Hashi S, Goodwin CR, Ahmed AK, Sciubba DM. Management of extranodal lymphoma of the spine: a study of 30 patients. 2018:7, http://dx.doi.org/10.2217/cns-2017-0033.

Coiffier B. Rituximab in combination with CHOP improves survival in elderly patients with aggressive non-Hodgkin’s lymphoma. Semin Oncol. 2002;29 2 SUPPL. 6:18-22, http://dx.doi.org/10.1053/sonc.2002.32749.

Chang CM, Chen HC, Yang Y, Wang RC, Hwang WL, Teng CLJ. Surgical decompression improves recovery from neurological deficit and may provide a survival benefit in patients with diffuse large B-cell lymphoma-associated spinal cord compression: A case-series study. World J Surg Oncol. 2013;11:1, http://dx.doi.org/10.1186/1477-7819-11-90.

Akgül T, Bilgin Y, Karademir G. The great mimicker at thoracolumbar spine: NonHodgkin’s lymphoma. Int JSurg Case Rep. 2017;39:267-70, http://dx.doi.org/10.1016/j.ijscr.2017.08.034.

Peng X, Wan Y, Chen Y, Chen L, He A, Liao W, et al. Primary non-Hodgkin’s lymphoma of the spine with neurologic compression treated by radiotherapy and chemotherapy alone or combined with surgical decompression. Oncol Rep. 2009 May;21:1269-75, http://dx.doi.org/10.3892/or00000350.

Tang Y, Yang X, Xiao J, Liu K, Yan W, Song D, et al. Clinical outcomes of treatment for spinal cord compression due to primary non-Hodgkin lymphoma. Spine J. 2013;13:641-50, http://dx.doi.org/10.1016/j.spinee.2012.11.054.

Published

2022-10-18

How to Cite

1.
Martín-V H, Sánchez-Correa CA, Herrera-Méndez FM, Montero-Silva CS. Medullary compression after diffuse large B cell lymphoma at thoracic spine in an undiagnosed HIV positive patient: A case report. Rev. Colomb. Ortop. Traumatol. [Internet]. 2022 Oct. 18 [cited 2025 May 10];36(4):255-9. Available from: https://revistasccotorg.biteca.online/index.php/rccot/article/view/118

Issue

Section

Case report